Diversified market demand for the hottest medical

2022-07-26
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Diversified market demand for medical plastic packaging film

medical plastic packaging film is widely used, not only for the packaging of tablets, powders and granules, but also for the lining of paste, liquid and drug carton packaging, as well as the packaging of medical devices. Common films include shrink film, winding film, multi-layer composite film, etc. In the pharmaceutical packaging, the glass bottles and plastic bottles used in the past are gradually replaced by plastic films, especially the medical liquid plastic flexible packaging such as infusion bags and plasma bags are developing more rapidly. According to the U.S. industrial market research company F, so that the experimental machine has given full play to its maximum working efficiency, reedonia grouplnc The survey shows that the annual growth rate of global pharmaceutical packaging demand from 1997 to 2007 reached 4.3% (see Table 1). According to the research on the European drug packaging market published by the British market intelligence organization, the total annual sales volume in the European packaging market is US $3.246 billion, and the traditional Chinese medicine packaging films and bags account for 28%. The annual output value of China's pharmaceutical packaging industry is about 15billion yuan, with an average annual growth rate of more than 10%. In recent years, the application proportion of plastic products in medical packaging in China is rapidly increasing. Statistics show that the proportion of aluminum and plastic packaging for pharmaceutical tablets in China has increased from 10% in 1990 to 40% at present. Medical plastic film has become a new development hotspot of film. It is estimated that the demand for plastic packaging for pharmaceutical tablets and capsules in China will increase to 4billion in 2005. There are many kinds of medical plastic films. The widely used ones are PE, PP, pet, pen (polyethylene naphthalate) Pa, PVA, PVC, PVDC, PC and the newly developed cyclic olefin copolymer (COC). The Nobel Prize in physics in 2010 awarded these two physicists the largest amount of polyolefins. Diversified development of raw materials 1. PE according to the investigation report of mastio on the PE film market, PE medical plastic packaging film is one of the fastest growing varieties of plastic films. It is predicted that the global demand for PE medical plastic film will increase at an average annual rate of 7% in the next few years. The largest potential growth market of PE medical film is the anti infection medical products packaging bag, followed by disposable lining film, small packaging bag and film for medical device packaging. At present, more than 40 companies around the world produce medical PE packaging products. The top five companies are clopay Corp., P1ant, maxxin Medical Products Co., Ltd., Rexam medical packaging Co., Ltd. and Banta health care Co., Ltd., with a market share of about 50%. LLDPE is the fastest growing PE medical film. In 2003, the consumption of LLDPE medical film accounted for 52% of the total PE medical film consumption in the market, and it is expected to reach 54% in 2006. The main source of the rapid development of LLDPE medical film at present, the fatigue testing machine is divided into mechanical, electromagnetic resonance and electro-hydraulic servo. Because it can produce films with higher strength than LDPE under the same thickness, it can produce thin films, save raw materials and reduce costs. In recent years, the annual output of LDPE medical film has exceeded 40000 tons, accounting for 39% of the total consumption, ranking the second. The consumption of HDPE and MDPE is small, and the market share is less than 10%. 2. The blend of PP metallocene catalyzed vinyl plasticizer and PP can improve the embrittlement resistance of PP film after irradiation, and can be used in the packaging of medical devices. In recent years, through the modification of PP, it has made great progress in the development of pharmaceutical liquid packaging bags. After screening the raw materials, buxter believes that if PP is used to make flexible packaging bags for medicinal liquids, it needs to integrate the high melting point of isotactic PP and the elastic block structure of flexible pp. these two materials have excellent softness and flexibility, good low-temperature toughness and melting point higher than 121oc. At the same time, their density is about 30% lower than that of PVC, so the unit cost is close to that of PVC. It is reported that the flexible polyolefin fpos of montellcataloy copolymer company and Huntsman company have met the above requirements. At present, rxloy products have been produced in the United States and Asia, and production licenses have been obtained in Europe. However, the crystallinity of fpos is 17%~25% lower than that of pp99% and has certain viscosity, which is difficult to handle. Therefore, it is usually necessary to improve its performance through blending. For example, adflexks353 with a density of 0.89g/cm3 must be used as the surface layer to ensure its strength and melting point above 121oc. The surface layer needs to use a special resin with high transparency level to provide the required transparency. In addition, the disadvantage of high haze on PP surface can be overcome by CO extrusion process. The heat sealing performance of PP can be improved by formula design. The thickness can be reduced and the cost can be reduced by using PP resin with a density of 0.89g/cm3. Amoco and Stanford University jointly developed PP elastomer with similar PVC properties. MLLDPE developed by Exxon and Dow Chemical is also being tried in medical liquid flexible packaging bags. They have excellent cleanliness, transparency and mechanical properties, and also have the potential cost advantage of reducing the film thickness. However, mLLDPE has a low melting point and can not be used for disinfection treatment at 121oc for 20min. Therefore, it is mainly used as a collection bag for human excretion liquid. If it is used as an infusion bag or blood transfusion bag, it needs to be further modified. In the development process of polyolefin as a substitute for PVC, special polyolefin resin is required for medical products in the processes of disinfection, sterilization, filling, sealing and use. Therefore, the high cost has become one of the important reasons why polyolefin can not quickly replace PVC. However, by changing the processing conditions and using new additives, the performance of PP has been gradually improved in recent years. In addition, problems related to the assembly line, such as heat sealing and disinfection conditions, can be solved through equipment improvement. Therefore, it is just around the corner that PP film can be used in the fourth generation infusion bags and plasma bags. 3. PVC PVC has good chemical resistance, mechanical properties and electrical properties, but poor light resistance and thermal stability. PVC film can be produced by calendering or extrusion blow molding. As PVC is a heat sensitive resin with high hardness, heat stabilizers and plasticizers must be added during the processing of soft films. Its soft and semi-hard films can be widely used in medical infusion bags and blood transfusion bags. When used in medical packaging materials, the content of vinyl chloride monomer in PVC resin should be less than LMG/kg. Non toxic heat stabilizers and non-toxic and non migratory plasticizers should be used to ensure the safety of products. The hard PVC film can be used as the film for drug packaging, mostly transparent or amber film, which is filled with tablets after vacuum forming the small recess, and then compounded with the cover material coated with EVA heat sealing agent. In order to improve the heat sealing with the cover material, the PVC inner layer is also coated with EVA or PVDC coating. In recent years, due to the environmental problems caused by the fact that phthalate plasticizers used in PVC flexible packaging are considered toxic and PVC flexible packaging bags are not easy to be recycled after use, serious threats and challenges have been encountered in the use, especially in some European countries, the PVC pharmaceutical packaging market is gradually shrinking. 4. Pa Pa film has strong toughness, good puncture resistance, durability and chemical resistance. It has a wide temperature range, but has large moisture absorption and poor heat sealing performance. Therefore, it is often used with polyolefin and other composite films. Because the good comprehensive performance of PA film is very suitable for protecting the sterilized medical devices during storage and transportation, medical device packaging will be a new application field of PA film. 5. CTEF film CTFE film is made of ethylene/chlorotrifluoroethylene copolymer, which has high transparency, flame retardancy and permeability resistance; Excellent. The film has a unique application range. It is still soft below - 195.50c, and its melting point is 182~204oc. 6. Pet biaxially stretched PET film has very high mechanical strength and rigidity, high heat resistance, good drug resistance, excellent transparency and gloss, small water and oxygen permeability, and good taste retention and non toxicity. PET film can be directly used in contact with drugs, and is often used in the packaging of tablets, especially traditional Chinese medicine tablets. In addition, because of its high flavor retention and heat resistance, it can be used as a barrier layer in the multilayer composite film to ensure that the tablets will not deteriorate within the validity period. Composite film and thin coating are the development trend. The basic requirements of pharmaceutical packaging materials are to prevent the contents from deterioration, and the main measures are to prevent moisture; Gas blockage;: Keep away from light, sterile and heat sealed. In addition, in order to ensure the quality of contents and the safety of filling, packaging, storage and transportation, packaging materials are also required to ensure that the contents are stable, heat-resistant, and will not produce harmful substance migration and other health properties; At the same time, the material is required to have certain tensile, impact, puncture and tear strength. At present, there is no single-layer film with the above functions. The multi-layer composite film or coated film made of two or more layers of multi-layer composite and multi shell composite can learn from each other and meet many requirements. 1. LDPE, a representative product, can be compounded with a variety of polyolefins to make flexible packaging bags, such as the medical liquid packaging bag produced by howadenkok company, whose raw materials are LDPE and ethylene-- α Copolymers of olefins. It can withstand high-temperature sterilization treatment above 1000C and has good flexibility. The multi-layer composite film made of LDPE, adhesive, PA and other raw materials has the advantages similar to PVC and PP and is widely used. PP film can be widely used as inner and outer layer materials of composite film for medical flexible packaging. BOPP has good transparency, heat resistance and impermeability, and is used for the outer layer of composite bags. The physical and mechanical properties of the composite film can be improved by compounding it with LDPE, EVA, EEA, EAA or aluminum foil; If the BOPP base film is coated with PVDC with excellent moisture resistance and permeability resistance, its gas and moisture resistance performance can be improved. Cast PP film (CPP) has good heat sealing property. It is mostly used in the inner layer of composite packaging bags. After vacuum aluminizing, it can be compounded with BOPP, pet, OPA and Pt. It is an important material for drug packaging. PVDC coated composite film has been widely used in pharmaceutical packaging, which can play the role of moisture resistance, taste preservation, moisture resistance and so on. At present, PVDC in the market is actually a copolymer of vinylidene chloride (VDC) and vinyl chloride or acrylic monomer, and the monomer content is usually 75%~90%. PVDC has the characteristics of transparency, flexibility, oil resistance, chemical resistance and excellent gas and moisture resistance. It is a widely used high-efficiency barrier material. In high barrier medical packaging, it is usually used as coating material, coating 2~4/μ M PVDC composite film can make its air permeability and moisture permeability most suitable for manufacturing blister packaging film of drugs and composite packaging bags for packaging low-cost drugs such as granular materials and powders. Vacuum aluminum coating is to evaporate aluminum onto various base films under high vacuum, and its aluminum coating is thin. At present, PETP, CPP and PT are widely used in the outer packaging of powders, granules and powders of traditional Chinese medicine; BOPP; Vacuum aluminum coating such as PE. The most widely used is PETP; CPP; PE vacuum aluminum coating. In addition to the characteristics of plastic base film, the film also has decorative and good permeability resistance. In particular, after aluminizing various plastic substrates, the light transmittance, oxygen permeability and steam permeability are reduced by dozens or hundreds of times. This kind of thin film used in drug packaging can prevent the drug from mildew, damp and deterioration. It is one of the main development directions of drug packaging materials in the future. CTFE films are inert in chemical properties and can withstand the erosion of strong chemicals that metals, ceramics and other plastics cannot withstand. In addition, the vapor permeability of CTFE film is lower than that of any other plastic film, without moisture absorption, and it can be compounded with various substrates such as PE, PVC, pet, PA, etc; CTFE films and their composites are mainly used for

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